Gregory Caplinger and His Cancer Scam

Stephen Barrett, M.D.

Gregory Earl Caplinger, alias Gregory Frazier, died in July 2009 while serving a 12-year prison sentence for fraud. For many years he claimed to be a distinguished and widely published medical doctor and researcher. However, he did not have a bona fide medical degree and made more claims and accumulated more questionable "credentials" than any other impostor I have ever investigated or heard of. He got into legal trouble at least six times for defrauding people. During the mid-1990s, he began operating a clinic in the Dominican Republic that offered treatment to desperate patients. In 2000, after a six-day trial, a North Carolina jury convicted him of wire fraud and money laundering related to "investments" in his phony remedy "ImmuStim." However, he did not show up for the verdict and remained at large for nearly a year before being captured. In 2001, he was sentenced to federal prison and ordered to pay more than $1 million restitution to his victims.  


The Elaborate Scheme

Caplinger claimed that ImmuStim—in various forms—was effective against cancer, AIDS, allergies, multiple sclerosis, chronic fatigue syndrome, and several other conditions. For several years, he administered it at the International Institute of Medical Science Hospital and Clinics (IIMS/HC) in Santo Domingo, Dominican Republic, whose literature identified him as "Gregory Earl Caplinger, MD, DSc., FACIP, FIAM." During 1996, one of his confederates (Charles David Weekley) solicited investors in Immuno Pharmaceuticals, a company that had been set up to market ImmuStim as an AIDS remedy [1]. These documents stated:

The general formula of the medicine is immune system stimulators, antioxidants, enzymes, and other biological agents in specific doses and combinations, including the following agents (the general formula):

Weekley's solicitation stated that the clinic had operated for 12 years, had treated more than 1,200 cancer patients, and was operated by Immuno Pharmaceuticals, Inc., and World Medical Services, S.A., Inc. The treatment, most forms of which are intravenous, was said to be administered daily for two weeks, three times a week for two weeks, twice a week for the second month, and once every other week for the third month. The solicitation summarized data said to be the results of clinical trials, but there was not enough detail to evaluate the reported results. Interleukin 2 and interferon have legitimate use against a few cancers. However, the solicitation stated that the doses Caplinger used were lower than those used for standard cancer care. Caplinger also said: (a) ImmuStim was manufactured in the Dominican Republic; (b) he discovered it and had sole control over its administration and research; and (b) Immuno Pharmaceuticals held a Dominican patent and had applied for a U.S. patent [2]. According to figures compiled by the FBI, approximately 15 people were swindled out of a total of approximately $230,000 they invested in Immuno Pharmaceuticals stock [1]. Another investor who had signed a contract to invest $2.3 million pulled out after concluding that something was wrong.

A brochure distributed in 1999 described IIMS/HC as "a division of the parent Company, THE RAPHAH GROUP, LTD, which is a well known organization serving Latin America and the Caribbean in the area of health care and medicine." The brochure described IIMS/HC as "one of the most progressive and innovative facilities in the world." It further described the facility as having"100+ private rooms" and as "a full service hospital with the most modern full service facilities in the world." The building, pictured in the brochure, is six stories high [3]. However, three people who visited the facilities told me:

Cost of Treatment

Another IIMS/HC brochure stated that the "cost levels" ranged from $3,000 -$6,000 for "General" care to more than $80,000 for "Level Four" care [4]. Five people who contacted me have described costs ranging from $40,000 to $85,000. The brochure stated that "most therapies are reimbursed by private medical insurance plans" except for HMOs, and ICD-9 or CPT code numbers are provided for submitting insurance claims. Most private insurance policies do not cover nonstandard treatment. Therefore, if insurance companies actually paid for Caplinger's services, I suspect they didn't realize what was involved.

Some patients made their arrangements through Nancy Wayne, R.N., of Allenwood, Pennsylvania, whose letterhead in 1999 described her as director of IIMS's North American Office of Patient Affairs. She distributed information packets, arranged for a telephone interview with Caplinger, and told prospective patients how to obtain instructions for wiring payment to a bank in Santo Domingo. Wayne has also identified herself as assistant executive director of The Gift of Hope Cancer Foundation, a Delaware-based organization claimed to offer "funding, after approval, for such support as conventional treatment, alternative treatment, traveling expenses and medical assistance not covered by insurance." [5] Although a letter from Wayne stated that contributions to the foundation are tax deductible, the foundation letterhead stated "A Non-Profit Organization . . . Application Pending." [5]

One patient who made arrangements through Wayne told me she was asked to fax her medical records to Caplinger, who replied:

After much review and evaluation of your specific case we will be able to consider your admission. . . . Your current condition is unstable to say the least and we will need to move aggressively. . . . Due to our limited admission of foreign patients you need to call this Administration this day.

The patient had had a colon cancer surgically removed nine months previously. Although follow-up tests had found no evidence of cancer, she contacted Caplinger because she thought that an unconventional treatment might boost her immune system to reduce the odds of recurrence. She states that Caplinger persuaded her to come by telling her that a small Nabothian cyst, mentioned in an ultrasound report, "could go either way" and therefore she needed immediate treatment. The estimated cost was $80,000 to $90,000, with a $40,000 advance deposit. Frightened by the thought that the cyst could become malignant, she wired the deposit and went for treatment. Nabothian cysts are plugged glands that pose no health threat and have nothing whatsoever to do with cancer. Shortly after arriving at Caplinger's clinic, the patient realized she had been defrauded, demanded a refund, and got back $20,000.

Dubious "Credentials"

Caplinger claimed to havean I.Q. of 210 and be a "Professor emeritus at various universities and a Professor of Medicine." [4] An IIMS/HC booklet stated:

Dr. Gregory E. Caplinger is both a scientist and a clinical physician. It has been Dr. Caplinger's goal and experience through the years to combine the pure scientific with practical clinical application.

He is a European (British) and U.S. trained physician with his medical residency and further subspecialties of clinical oncology/immunology. He currently continues his post-graduate medical education both in Europe and the United States, where he regularly attends courses at Harvard Medical School, Division of Continuing Education. His board certifications include Internal Medicine/Clinical Oncology.

In conjunction with his medical studies, Dr. Caplinger completed a Doctor of Science (D.Sc.) in Biochemistry/Immunology. It is in these disciplines that he continues his research and writing of articles.

He has published 26 articles as primary author and written a laboratory manual entitled "Practical and Clinical Immunology for the Classroom. He recently completed a textbook titled "Progressive Immunology" (Released in 1996).

His past and present accomplishments are noted and include the "Caribbean International Prize in Medicine" (international prize given to scientists that have contributed vital information in the area of Medicine. He is also a member of many scientific/medical organizations where he has also held positions of leadership. Further, Dr. Caplinger has recently (1995-1996) been named as an entry to the national publication International Who's Who of Contemporary Achievement, recognized for Excellence in Medicine and Science. Dr. Caplinger is also very active in teaching and lecturing worldwide. [6]

His biographical sketch in the International Who's Who of Contemporary Achievement read:

Physician. Personal: Born March 25, 1953; Son of Louis Earl (deceased) and Neva Marie Caplinger. Education: B.A., Biology, Indiana University, 1974; D.Sc., Biochemistry/Immunology, Sussex College of Technology (UK), 1987; M.D., Metropolitan Collegiate Institute (UK), 1982. Physician, Institute of Medical Science 1987 to present, Centro de Ottornolarigologia & Sussex General Hospital, 1979 to present; Director of Research, Immuno-Oncology, Immuno Pharmaceuticals (U.K., U.S.A., D.R.), 1984 to present; Professor of Medicine, Utesa School of Medicine, Dominican Republic, 1989-92. Organizational Memberships: American College of International Physicians (fellow, 1993 to present); Board Certified, British College of Physicians and Surgeons, 1988 to present. Community Activities: Minister of Health, British West Indies Health Confederation (non profit medical organization for developing nations), 1990-94. Published Works: Author. "Treatment of HIV/AIDS Infected Patients with Biological Response Modifier-ImmuStim-V" in Progressive Immunology, 1994. Honors and Awards: Caribbean International Prize in Medicine, 1987; ANMA Doctor of the Year, 1985. [7]

Except for the biology degree, all of the above credentials were bogus or questionable.

Caplinger's Progressive Immunology [15] does not resemble any textbook I have ever seen. During a half-hour scan, I spotted about 200 spelling errors. The book's 223 pages included a few introductory pages, 11 chapters, and a 2-page list of references. Four chapters resembled standard texbook chapters with citations (the author's last name and publication date) embedded in the text. However, no references corresponding to these citations were listed anywhere in the book. I suspect that he lifted these chapters from standard textbooks but forgot to include the references. Most other chapters mention no references at all, except where charts or drawings are used. One chapter (about "homeotoxicology") is pure gobbledygook. The final reference list is not numbered and is neither in alphabetical nor chronologic order. The only citation later than 1984 is a report written by Caplinger himself. Considering how rapidly medical science is advancing, do you believe that a textbook whose references are at least 12 years old could be valid? Caplinger probably figured that the people who saw it would not know enough about the subject to see that the book was a fake.  

Schemes and Prosecutions

In 1984, the Florida Department of Professional Regulation investigated complaints indicating that Caplinger had been practicing medicine without a license. The case was settled without prosecution because Caplinger signed a cease-and-desist agreement, said he had terminal cancer and was moving to France for treatment, and indicated that he had no intention of returning to Florida.

The IIMS/HC brochure stated that "for the last 20 years Dr. Caplinger has made his home in the Dominican Republic." [4] However, investigative reports indicate that, in 1986, he operated the "Natural Health and Therapy Clinic" in Boone, North Carolina, while falsely representing that he had valid medical and naturopathic credentials. Later that year, he closed this facility but began seeing patients in the office of a chiropractor in Blowing Rock, North Carolina. During 1987 and 1988, Caplinger operated the Blue Ridge Health Clinic in Blowing Rock while advertising in the 1987 and 1988 Yellow Pages as a "Naturopathic Physician, Registered with the Board of Naturopathic Physicians." A reporter who investigated found that no such state board existed but the telephone directory had a listing for the "NCB of NP" at the same address as Caplinger's office. During this period, Caplinger claimed that he had cured himself of cancer using "natural healing" techniques.

Near the end of 1988, after Caplinger had practiced illegally for more than three years, North Carolina authorities charged him with practicing medicine without a license. He left the area shortly after his arrest. In 1989, his attorney entered a plea of guilty to the charge, and Caplinger received a two-year suspended prison sentence and was fined $500, the maximum penalty allowed by North Carolina law [16]. During the period in which Caplinger was being investigated, a North Carolina official informed me that Caplinger had more than 30 certificates on his office wall. One of them was a "Doctor of Medicine" degree from the British West Indies Medical College [10], a correspondence school Caplinger himself operated (or pretended to operate). During the late 1980s and early 1990s, Caplinger also sold "interest" in this school.

While operating the Blue Ridge Medical Clinic, Caplinger acquired an associate named Laurence Perry [10], whose credentials included a "diploma" from the British West Indies School of Medicine. In 2002, Perry was convicted of involuntary manslaughter and practicing medicine without a license following the death of an eight-year-old diabetic child whose mother followed Perry's advice to stop administering insulin [17]. Another individual sporting a medical degree from this "school" was Joel Robbins, who operates the Health & Wellness Clinic of Tulsa, Oklahoma. Robbins, a licensed chiropractor, also has a naturopathic "degree" from the Anglo-American Institute of Drugless Therapy, which is a diploma mill.

In 1993, Caplinger was charged in Florida with two counts each of financial exploitation of the elderly, grand larceny, and practicing medicine without a license. The investigator's report indicates that in 1990, while working in Florida as a medical assistant, Caplinger persuaded two elderly women that he was a "world renowned doctor" with a clinic in Santo Domingo and could help their husbands, who had Alzheimer's disease. After the treatment failed to help, the women realized that they had been duped and complained to the authorities [18]. The "Alias/Street Name" box on the arrest record has the entry "Gregory Frazier." [19] A report from the Florida Department of Law Enforcement (FDLE) states that the case was settled with a guilty plea and a "no contest" plea to reduced charges of "theft to deprive." Caplinger was placed on nonreporting probation for one year and ordered to return the victims' money [20].

In 1996, Caplinger was arrested in Broward County, Florida, on ten counts of racketeering (RICO) and grand theft [21]. The charges related to a 1993 scheme that defrauded chiropractors of "tuition" paid to attend his "medical school" in the Dominican Republic. More than 120 individuals paid several thousand dollars each. In 1997, the charges were dismissed after Caplinger agreed to make partial restitution. According to a report in Dynamic Chiropractic, Caplinger pretended to operate two entities: the "British West Indies Medical School" and the "Universidad Federico Henriquez Y Carvajal," to which students would supposedly transfer after nine weeks of preparatory coursework [22].

In 1999, a federal grand jury indicted Caplinger, Charles David Weekley, and Harry J. Kampetis on one count of conspiracy and a total of 21 counts of wire fraud. The indictment stated that Weekley began soliciting money in 1992 and became partners with Kampetis in 1993 in schemes in which investors were promised very high rates of return. In 1995, after losing more than $2 million in various trading programs, the pair incorporated Immuno Pharmaceuticals to market Caplinger's alleged AIDS treatment and began transferring money to Caplinger without informing the investors they were doing this. (Caplinger apparently used some of the money to make restitution to his "medical school" victims.) According to the indictment, Caplinger falsely represented to Weekley and Kampetis that he was an accomplished and published medical doctor and was a candidate at one time for the Nobel Peace Prize for his work involving AIDS patients; and Weekley and Kampetis promoted Caplinger's medical program on this basis. The indictment concluded that over a five-year period Weekley and Kampetis raised approximately $4.9 million from investors and "paid approximately $764,192 in interest to the investors in order to give the appearance of validity of the investment schemes." (Swindles in which early investors are paid off with funds raised from later ones are called "Ponzi schemes.") Caplinger's share of the indictment included six acts of wire fraud totaling $1,039,000. [1]

In 1999, an FBI agent and I testified at a detention hearing about why we did not think Caplinger should be trusted to be released on bail. On the following day, he surprised everyone by pleading guilty and was permitted to reside with his mother in Indiana until the time he was sentenced. The release terms included: (a) remaining in Indiana, (b) electronic monitoring of his whereabouts, (c) surrender of his passport, (d) a ban on providing any type of health-care service or soliciting of investors, and (e) a $100,000 performance bond (secured by his mother's house). In 2000, a judge permitted Caplinger to rescind his guilty plea, and later he permitted Caplinger to leave Indiana to help prepare his defense. In March, two counts of money laundering were added to Caplinger's indictment. Weekley and Kampetis pled guilty to all of the charges against them.

In July 2000, after a six-day trial. a jury convicted Caplinger on all counts, During the trial, government witnesses made it crystal clear that Caplinger's claim to be a medical doctor was bogus [23]. They also exhibited photographs of several buildings mentioned in Caplinger's documents. The address for the Sussex General Hospital was occupied by an answering service; the "Florida Degenerative Disease Center" address was that of a liquor store; and so on. Caplinger did not show up to hear the jury verdict but fled with his fiancée (Flabia Berroa) to the Dominican Republic. In July 2001, he was apprehended and returned to the United States for sentencing. In October, the judge gave him the maximum sentence permissible under federal sentencing guidelines.

In March 2001, a federal Grand Jury for the Eastern District of Pennsylvania indicted Caplinger on 39 counts of wire fraud in connection with patients seen at his Dominican clinic [24]. In 2002, he pleaded guilty to one count and was sentenced to 5 years in prison, 3 of which would run consecutively and 2 of which would follow his previous sentence. He was also fined and ordered to make restitution of $484,545.

In July 2001,Weekley was sentenced to 15 months in prison, to be followed by three years supervised release, Kampetis was sentenced to 5 years probation, and the pair were ordered to pay restitution of $4,365,082.

While in prison, Caplinger appealed his sentence and got it reduced by about three years [25]. His projected prison release date became July 28, 2012. However, he died in 2009 while still in prison.

A Chiropractic Connection

My files also contain a brochure from a chiropractic vitamin company that invited chiropractors to attend a seminar on November 21-22, 1987, during which Caplinger would "share his vast knowledge on clinical endocrinology and laboratory medicine." The brochure, pictured below, specified that he would: (a) teach how to provide "nutritional support" for the pituitary, pineal, gonads, thyroid, adrenal, thymus, and pancreas; (b) consider the complete evaluation of a patient's blood work, metabolic laboratory studies, amino acid studies, and allergy-evaluations; and (c) deal with specific diseases and nutritional support of allergies, cardiac diseases, hypertension, arteriosclerosis, amenorrhea, arthritis, pulmonary diseases, candida, digestive disorders, emotional disorders, reproductive disorders, neurological disorders, gallbladder disease, immunologic disease (including cancer, AIDS and multiple sclerosis), hypoglycemia/diabetes, and thyroid. The brochure also contained an interesting biographical sketch:


Dr. Caplinger is a well known physician, researcher and speaker throughout the world. Currently he is director of research at Blue Ridge Oncology Research Center, where the main areas of research are directed towards an immunological approach for the treatment of cancer.

Dr, Caplinger serves as chief consultant in Nutritional Immuno-Oncology for World International Hospital Consulting Group, West coast oncology Consultants, and American International Hospital in Zion, Illinois.

He has published extensively in the Journal of Cell Biology, Journal of Molecular Biology, and Journal of Developmental Biology. He is currently completing a textbook in the area of Clinical Endocrinology and Laboratory Data for the practicing holistic Physician.

Recently Dr. Caplinger was presented with the coveted Caribbean International Prize in Medicine for his research in the area of cancer and immunology. He was also named as Doctor of the Year (1987) by the American Nutritional Medical Association.

The American Nutrimedical Association (AMNA), mentioned in the above brochure, was a paper mill that issued dozens of different spurious credentials, including "professional membership" certificates to anyone who sent $50, and a Doctor of Nutritional Medicine (NMD) "degree" to anyone who claimed to have another doctoral degree and sent $250. AMNA's 1987 directories listed Caplinger's credentials as "NMD, MD, MDE, FACN, FANMA" and included Nutri-West among its affiliates. Other AMNA literature indicates that MDE stood for "Doctor of Eclectic Medicine," FACN stood for "Fellow of the American College of Naturopathy," and FANMA stood for "Fellow of the American Nutritional Medical Association."

Despite what the brochure says, I could find no information supporting the claim that Caplinger was "a well-known physician, researcher and speaker throughout the world." On several occasions, I searched the MEDLINE, AIDSLINE, and CANCERLIT databases for "Caplinger G" and found no record of any scientific publication under that name.

Caplinger's "Investigator"

On June 4, 1999, I was telephoned by Keith M. Krasnove, J.D., president of Corporate Security Investigations and Litigation Services, of San Jose, California. In a follow-up letter, Krasnove stated that Caplinger had retained him to investigate whether articles appearing on Quackwatch "had defamed Dr. Caplinger, and if so, to either seek your prompt compliance in correcting the offending passages or to recommend other relief available to Dr. Caplinger via litigation." [26] Krasnove claimed that I had erroneously left readers "with an inference that Dr. Caplinger neither has a bone-fide medical doctor degree nor is validly licensed as a medical doctor in any jurisdiction." Krasnove's letter stated:

I have enclosed a copy of Dr. Caplinger's diploma for the degree of Doctor of Medicine awarded by Universidad Autonoma de Santo Domingo. This University was the first University in the new world and was chartered on October 28, 1538. It is recognized and accredited by the U.N. World Health Organization. Dr. Caplinger's former degree was re-certified. In addition, as proven by the enclosed exhibits, Dr. Caplinger was required, as a condition to receiving the degree from this institution, to take written, oral, and practical examinations in OB/GYN, Pediatrics, Surgery, and Internal Medicine [26].

Krasnove's letter was accompanied by several documents written in Spanish, which a local teacher translated for me:

Krasnove also stated that the original 1993 charges in Florida were either "nolle prossed" (not prosecuted) or dismissed; that Caplinger did not admit guilt; that he pleaded only "no contest" to a misdemeanor charge of "petit larceny"; and that Caplinger received a "withhold adjudication of guilt, which means that he had not been convicted." To document his description of what happened, Krasnove enclosed a partially indistinct 1-page "court status report" indicating that Caplinger "pled nolo" to two charges (rather than one as stated in the document FDLE had issued in response to my request). Krasnove further indicated that he would ask FDLE to verify that Caplinger did not plead guilty to any charge in 1993. However, he sent me no additional documents.

The bottom-line issues, of course, were whether Caplinger was competent to practice medicine and whether he accurately represented his credentials and professional activities. With this in mind, I posed the following questions to Mr. Krasnove:

Neither Krasnove nor Caplinger ever responded to the above request. When I investigated further, I found that before moving to California, Krasnove practiced law in Florida but got into serious trouble:

To get reinstated from the 1997 and 1998 suspensions, Krasnove was required to comply with the terms of his suspension, "reveal of sense of repentence," and provide "evidence of unimpeachable character and moral standing in the community." [25] In January 2000, a Supreme Court referee denied Krasnove's petition for reinstatement because he had: (a) failed to make appropriate restitution, (b) failed to give timely notice to a client that he was about to be suspended, (c) failed to give timely notice to another client that he has been suspended, (d) issued a former client a refund check that bounced, (e) compromised a former client's case by failing to return certain documents on time, and (f) failed to return about $3,000 to insurance companies he had represented that were entitled to certain refunds [25]. The referee also assessed costs of $2,509.30. In 2001, after investigating additional complaints, the Bar Association recommended that Krasnove be disbarred and, in October 2002, the Supreme Court of Florida disbarred him for a period of at least five years [30]. In 2004, he was disbarred in New York State [31].

Additional Findings

In August 1999, in connection with Caplinger's detention hearing, an FBI agent showed me a 70-page booklet called "Curriculum Vitae of Gregory Caplinger, M.D.,"which contained long lists of Caplinger's supposed educational and training (14 items); research and professional activities (22 items, including positions held simultaneously in the Dominican Republic, British West Indies, England, Colorado, and California); honors and awards (17 listed); board certifications (7), licenses/registrations (6), professional memberships and affiliations, important certificates and honors (10) reference letters (8); and "major articles." [32] The most noteworthy were:

Bogus "Clinical Results"

The documents I have collected contain many claims about Caplinger's success. His "textbook" provides data on 18 patients divided into six groups of three, of which half received only Caplinger's "immunotherapy" (using various protocols), and half received his treatment plus standard surgery and chemotherapy (elsewhere). The summary table covers the patient's age, type and stage of cancer, diagnosis date, immunotherapy starting date, and "current status." The patients who underwent standard therapy all had breast cancer, but those who did not included six patients with other tumors. (In other words, the groups were not comparable.) Dates are missing from 3 patients in the table's "diagnosis date" column, 2 in the "immunotherapy started" column, and 11 in the "current status" column. The treatment dates ranged from July 1986 to February 1987, and the follow-up entries ranged from October 1986 to December 1987, during which time six patients died. (During this period, Caplinger was practicing in North Carolina. The report does not indicate where the patients were treated.) Of patients described as "currently living"—either cancer-free or with "stabilized" tumors, only one had a follow-up date specified—so that it is impossible to tell when Caplinger concluded whether or not they had been helped. Nevertheless, he concluded that some of the data "tended to indicate" that one of his protocols "enhanced" standard treatment and "will indeed give our patients a much greater chance for survival or at least improve their quality of life." Science-based reports on treatment outcome ordinarily provide 5-year follow-up data. Even though this report appears in a 1997 book, it does not appear that any of the patients were followed for longer than ten months. During my entire medical career, I have never seen a more pathetic-looking report.

The report Caplinger distributed in 1996 (to prospective investors in his company) included one-line summaries of average results for 26 groups of patients—each group representing a tumor type—totaling 125 patients "randomly selected" from 1,275 patients he claimed to have treated. In discussing these results, Caplinger states that 128 patients were treated, 76 were in remission, 101 were living and in remission, and 27 were deceased. He does not explain why there were three more patients in his summary than in his table or how the number of patients "living and in remission could be greater than the total number of patients "in remission." Although the table has columns for tumor stage (severity), treatment type, and post-treatment status, the grouping makes it impossible to judge either the severity of the disease or the treatment received by individual patients. Caplinger also states that his 1,275 patients had an 81.8% survival rate, compared to a 31.16% 5-year average survival rate reported by the American Cancer Society. To develop useful statistics, it is necessary to collect data systematically and to be sure that any comparisons are made on comparable patients. Caplinger said nothing about how the patients were diagnosed, how the staging was done, who did the staging, or how he collected his alleged follow-up data.

IIMS's "Physicians Manual" is a 350-page hodgepodge of photocopied textbook chapters, magazine articles, documents about radionics treatment (written by the proprietor of the Sussex College of Technology) and live-cell analysis, statements by Caplinger, and various statistics [30]. Six pages provided "Reports from Independent Physicians 1987-1994 (Eleven Patient Summaries)." The "independent physicians" were not identified. The summaries described 8 patients with cancer and 2 with HIV/AIDS. The reports were very skimpy and contained no dates indicating how long the patients were followed after treatment. The longest follow-up described in the text of any of the reports was two years. One report simply stated:

PATIENT #007 (CASE 1026)
52 year old American with a diagnosis of adenocarcinoma of breast (3/85)
1. Adenocarcinoma of breast
2. Metastatic disease to bone
Treatment: 3/85-3/87
1. ImmuStim-CA/CAP Immunological Protocol
2. Mastectomy
Condition: Cured.

The reports were preceded by a disclaimer that, "This information is anecdotal and written in lay terms for the benefit of interested persons. Therefore, it is not a scientific publication nor a study with an objective to prove the existing protocol."

Caplinger's 1998 "Advances" booklet stated that, during the previous five years, his "various centers and associates" had used his protocols to treat more than 22,000 patients with multiple sclerosis, ALS (amyotropic lateral sclerosis), severe allergies, rheumatoid arthritis, psoriasis, chronic sinusitis, fibrocystic breast disease, Epstein-Barr Virus, autoimmune disease, hypothyroidism, lupus, diabetes, chronic candidiasis, severe vitamin deficiencies, asthma, and "various metabolic imbalances," in addition to "thousands" of cancer and HIV/AIDS patients [6]. The idea that Caplinger had "other centers" was contradicted by a disclaimer that "all information and treatment originated in and from The Dominican Republic." The booklet also claimed that Caplinger's "ultramodern cutting-edge immunology laboratory" enabled him to "detect physical problems before they reach the disease-state."

The "Advances" booklet discussed 100 patients selected randomly from over 1,500 patients who were screened and evaluated for cancer. However, the table contained data for only 50 plus a statement that the results on the remaining 50 were similar. This time, the longest follow-up period was 36 months. Twelve patients with summaries in the table were said to be "cancer-free" after periods ranging from 8 to 32 months. However, a table summarizing the results of all 100 patients said that 60 who received Caplinger's treatment were cancer-free after an average of 36 months (although 7 of these were also reported as deceased after an average of 7 months). In yet another table, Caplinger claimed that his data showed that patients who received ImmuStim plus chemotherapy had a 40.3% better response than patients receiving chemotherapy. He also claimed that his 5-year survival rate was 86%, compared to the standard treatment rate of 35%. (Of course, he provided no actual data or description of how any follow-up data were collected.) He also claimed that 100% percent of patients reported "a marked improvement in their quality of life."

Even if Caplinger's reports had been designed so that the data could be meaningfully interpreted, there's no reason to believe that the numbers were any more trustworthy than his credentials.


  1. Bill of indictment. United States of America v. Charles David Weekley, Harry J. Kampetis, and Gregory E. Caplinger. United States Court for the Western District of North Carolina, Statesville Division, July 12, 1999.
  2. Caplinger GE. Letter to prospective investor. July 30, 1996.
  3. International Institute of Medical Science Hospital and Clinics. Undated brochure distributed in 1999.
  4. General information, International Institute of Medical Science Hospital and Clinics, undated, distributed in 1999.
  5. Wayne N. Undated letter distributed in 1999.
  6. Caplinger GE. Advances: Immu Stim-CAP Immunological Protocol. Santo Domingo, Dominican Republic: International Institute of Medical Science, 1998.
  7. International Who's Who of Contemporary Achievement. Raleigh, NC: American Biographical Institute, 1996.
  8. American Medical Directory: Physicians in the United States, 30th Edition. Chicago: American Medical Association, 1986.
  9. Bear JB. Bear's Guide to Non-Traditional College Degrees, 9th edition. Berkeley, CA: Ten Speed Press, 1985.
  10. Davant C III. Health fraud—What's going on in North Carolina? North Carolina Medical Journal 50:341-346, 1989.
  11. Medi-Net search, June 20, 1999.
  12. Jarvis WT. Telephone conversation with British Embassy official, 1981.
  13. Bear JB, Bear MP. Bear's Guide to Earning Degrees Nontraditionally, 13th edition. Berkeley, CA: Ten Speed Press, 1999.
  14. Sussex Police Department. Letter with attachments sent to the U.S. Justice Department, National Central Bureau - INTERPOL, Oct 18, 1990.
  15. Caplinger GE. Progressive Immunology. London, England: British Medical Publications, 1997.
  16. Davant C III. No medical degree, no license? Come practice here. Medical Economics, Dec 18, 1989, pp. 70-85.
  17. Zimmerman D. CV discloses a deadly phony. Probe 8(2):4-5, 2000.
  18. Meyers P, investigating officer, Florida Department of Law Enforcement. Affidavit, March 4, 1991.
  19. Broward County Sheriff's Office. Short arrest information form, April 23, 1993.
  20. Florida Department of Law Enforcement. Florida criminal history report on Gregory Caplinger, issued May 25, 1999, in response to my inquiry.
  21. Complaint affidavit. Broward County Sheriff's Office, July 31, 1995.
  22. Kelly S. DCs lured to foreign medical school. Dubious goings-on down Santo Domingo Way. Dynamic Chiropractic Archives, Jan 1, 1993.
  23. Indictment. United States of America v. Gregory E. Caplinger. United States District Court for The Eastern District of Pennsylvania. Filed March 29, 2001.
  24. Trial transcript, USA v Gregory E. Caplinger, July 17-25, 2000. Volume 1, Volume 2, Volume 3.
  25. Opinion. USA vs. Gregory E. Caplinger. U.S. Court of Appeals for the Fourth Circuit No. 01-49878, Aug 11, 2003
  26. Krasnove KM. Letter to Stephen Barrett, M.D., June 8, 1999.
  27. Oftedal RL. Report of referee. In re: Petition for reinstatement of Keith Martin Krasnove, practitioner. Florida Supreme Court Case No. 95,475, Florida Bar Case No. 99-51,604(17G)-FIRE, January 31, 2000.
  28. Florida Supreme Court. Discipline Release, Oct 27, 1997.
  29. Florida Supreme Court. Discipline Release, Nov 23, 1998.
  30. Florida Supreme Court. Order. The Florida Bar vs. Keith Martin Krasnove, October 22, 2002.
  31. Matter of Keith M. Krasnove. 2004 NY Slip Op 04342 [7 AD3d 111] June 1, 2004.
  32. Caplinger GE. Curriculum Vitae of Gregory E. Caplinger, M.D., Sc.D. Undated, but probably published in 1994 or 1995.
  33. Strathclyde Police Department. Letter with attachments sent to Scotland Yard on Dec 28, 1990.
  34. Physicians Manual. Santo Domingo, Dominican Republic: International Institute of Medical Science Hospital and Clinics. Undated, contains entries dated as late as October 1996.
  35. Barrett S. American Nutrimedical Association. Quackwatch, 1999.

This article was revised on February 7, 2019.

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